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Biología del ARN
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Descripción general
El objetivo de nuestro laboratorio en el estudio de la regulación génica guiada por ARN se centra en la función de los ARN no codificantes pequeños y largos que guían nuevos eventos nucleares. Estamos realizando un análisis detallado de los procesos de ARN nuclear mediante el estudio de la identidad, localización y funciones de moléculas específicas de ARN nuclear, complejos ARN/proteínas nucleares y procesos de transporte nuclear en Arabidopsis thaliana y Caenorhabditis elegans. Mediante estos análisis, esperamos caracterizar nuevas vías de ARN nuclear y descubrir su relevancia biológica.
Publicaciones Seleccionadas
Rosatti S, Rojas AML, Moro B, Suarez IP, Bologna NG, Chorostecki U, Palatnik JF.
Principles of miRNA/miRNA* function in plant MIRNA processing.
(2024) Nucleic Acids Research. DOI: 10.1093/nar/gkae458.
Martín-Merchán A, Lavatelli A, Engler C, González-Miguel VM, Moro B, Rosano G, Bologna NG*.
Arabidopsis AGO1 N-terminal extension acts as an essential hub for PRMT5 interaction and post-translational modifications.
(2024) Nucleic Acids Research. DOI: 10.1093/nar/gkae387.
Chorostecki, Bologna NG*, Ariel F*.
The plant noncoding transcriptome: a versatile environmental sensor.
(2023) The EMBO Journal.: DOI: 10.15252/embj.2023114400.
Guzmán-Benito I, Achkar NP, Bologna NG, Ursache R.
CRISPR/Cas-mediated in planta gene targeting: current advances and challenges.
(2023) Journal of experimental botany vol. 74,7: 2374-2388: DOI: 10.1093/jxb/erad072
Martín-Merchán A, Moro B, Bouet A, Bologna NG*.
Domain organization, expression, subcellular localization, and biological roles of ARGONAUTE proteins in Arabidopsis.
(2023) Journal of experimental botany vol. 74,7: 2374-2388.DOI: 10.1093/jxb/erad030.
Moro B, Kisielow M, Barragán V, Bouet A, Brosnan C, Bologna NG*.
Nuclear purification by Flow cytometry for RNA analysis.
(2021) STAR Protocols, Cell Press. DOI: 10.1016/j.xpro.2021.100320.
de Leone M.J., Hernando C.E., Romanowski A., Careno D.A., Soverna A.F., Sun H., Bologna N.G., Vázquez M., Schneeberger K., Yanovsky M.J.
Bacterial Infection Disrupts Clock Gene Expression to Attenuate Immune Responses.
(2020) Current Biology, 30(9), 1740-1747.
Rojas AML, Drusin SI, Chorostecki U, Mateos JL, Moro B, Bologna NG, Bresso EG, Schapire A, Rasia RM, Moreno DM, Palatnik JF.
Identification of key sequence features required for microRNA biogenesis in plants.
(2020) Nature Communications 11(1)5320.
Brosnan CA, Sarazin A, Lim P, Bologna NG, Hirsch-Hoffmann M, Voinnet O.
Genome-scale, single-cell-type resolution of microRNA activities within a whole plant organ.
(2019) EMBO Journal 38(13):e100754.
Bologna NG, Iselin R, Abriata L, Sarazin A, Pumplin N, Jay F, Grentzinger T, Dal Peraro M, Voinnet O.
Nucleo-cytosolic shuttling of ARGONAUTE1 prompts a revised model of the plant microRNA pathway.
(2018) Molecular Cell, 69(4), 709–719.e5.
Pumplin N, Sarazin A, Jullien PE, Bologna NG, Oberlin S, Voinnet O.
DNA Methylation Influences the Expression of DICER-LIKE4 Isoforms, Which Encode Proteins of Alternative Localization and Function.
(2016) The Plant Cell, 28 (11) 2786-2804.
Bologna NG, Voinnet O.
The diversity, biogenesis, and activities of endogenous silencing small RNAs in Arabidopsis.
(2014) Annual Review of Plant Biology 65:473-503.
Bologna NG, Schapire AL, Zhai J, Chorostecki U, Boisbouvier J, Meyers BC, Palatnik JF.
Multiple RNA recognition patterns during microRNA biogenesis in plants.
(2013) Genome Research 23(10):1675-89.
Bologna NG, Schapire AL, Palatnik JF.
Processing of plant microRNA precursors.
(2013) Briefings in Functional Genomics 12(1):37-45.
Bologna NG, Mateos JL, Bresso EG, and Palatnik JF.
A loop-to-base processing mechanism underlies the biogenesis of plant microRNAs miR319 and miR159.
(2009) EMBO Journal 28(23):3646-56.