Bacterial plant diseases and Plant cell death

Bacterial plant diseases and Plant cell death

Group Leaders
Núria Sánchez-Coll
CSIC Scientist
Marc Valls
UB Associate Professor
Group Members
Bacterial Plant Diseases and Plant Cell Death group


Our team is interested in understanding the molecular mechanisms that control the interaction between pathogenic bacteria and plants to develop sustainable strategies to prevent and fight bacterial invasions in the field.

Research in the lab focuses on 2 main areas:

  1. Understanding the genetic determinants of bacterial wilt: Bacterial wilt caused by the wide-host range pathogen Ralstonia solanacearum is a devastating disease affecting over 200 plant species from disparate families including potato, tomato, peanut, eucalyptus, clove, etc. Management of bacterial wilt remains difficult due to R. solanacearum aggressiveness, its broad geographical distribution and its long persistence in soil and water. We study the expression and the functions of R. solanacearum genes inside its plant hosts and search for novel virulence determinants that can be used as targets to control the disease 
  2. Understanding the molecular mechanisms that control defense responses to bacterial invasion in plants: resistance to R. solanacearum is multigenic and regulated by very complex characters. In the lab we study the mechanisms underlying inducible physico-chemical barriers posed by resistant plants to R. solanacearum as well as the protease complement involved in neutralizing the bacterium in the apoplast and xylem of infected plants. We also study the mechanisms regulating the hypersensitive response in plants, in particular the role of the metacaspase AtMC1 as a cell death protease and a homeostasis regulator


Group Web Page

Selected Publications

Alonso-Díaz, A., Floriach-Clark, J., Fuentes, J., Capellades, M., Coll, N.S., Laromaine, A.
Enhancing Localized Pesticide Action through Plant Foliage by Silver-Cellulose Hybrid Patches
(2019) ACS Biomaterials Science and Engineering (DOI: 10.1021/acsbiomaterials.8b01171)

Puigvert, M., Solé, M., López-Garcia, B., Coll, N.S., Beattie, K.D., Davis, R.A., Elofsson, M., Valls, M.
Type III secretion inhibitors for the management of bacterial plant diseases
(2019) Molecular Plant Pathology, vol. 20 (1), pp. 20-32

Planas-Marquès, M., Bernardo-Faura, M., Paulus, J., Kaschani, F., Kaiser, M., Valls, M., Van Der Hoorn, R.A.L., Coll, N.S.
Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato Lines
(2018) Molecular and Cellular Proteomics, vol. 17 (6), pp. 1112-1125

Lu, H., Lema, S.A., Planas-Marquès, M., Alonso-Díaz, A., Valls, M.*, Coll, N.S.*
Type III secretion-dependent and-independent phenotypes caused by Ralstonia solanacearum in Arabidopsis roots
(2018) Molecular Plant-Microbe Interactions, vol. 31 (1), pp. 175-184

Hofius, D., Li, L., Hafrén, A., Coll, N.S.
Autophagy as an emerging arena for plant–pathogen interactions
(2017) Current Opinion in Plant Biology, vol. 38, pp. 117-123

Lema Asqui, S., Vercammen, D., Serrano, I., Valls, M., Rivas, S., Van Breusegem, F., Conlon, F.L., Dangl, J.L., Coll, N.S.
AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta
(2018) New Phytologist, vol. 218 (3), pp. 1156-1166

Popa, C., Li, L., Gil, S., Tatjer, L., Hashii, K., Tabuchi, M., Coll, N.S., Ariño, J., Valls, M.
The effector AWR5 from the plant pathogen Ralstonia solanacearum is an inhibitor of the TOR signalling pathway
(2016) Scientific Reports, vol. 6, Art. number 27058

Popa, C., Coll, N.S., Valls, M., Sessa, G.
Yeast as a Heterologous Model System to Uncover Type III Effector Function
(2016) PLoS Pathogens, vol. 12 (2), Art. number e1005360

Olvera-Carrillo, Y., Van Bel, M., Van Hautegem, T., Fendrych, M., Huysmans, M., Simaskova, M., van Durme, M., Buscaill, P., Rivas, S., Coll, N.S., Coppens, F., Maere, S., Nowack, M.K.
A conserved core of programmed cell death indicator genes discriminates developmentally and environmentally induced programmed cell death in plants
(2015) Plant Physiology, vol. 169 (4), pp. 2684-2699

Coll, N.S.*, Smidler, A., Puigvert, M., Popa, C., Valls, M., Dangl, J.L.
The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: Functional linkage with autophagy
(2014) Cell Death and Differentiation, vol. 21 (9), pp. 1399-1408

Coll NS, Vercammen D, Smidler A, Clover C, Van Breusegem F, Dangl JL, Epple P
Arabidopsis type I metacaspases control cell death. 
(2010) Science 3; 330(6009): 1393-7

Valls M, Atrian S, de Lorenzo V, Fernández LA. 
Engineering a mouse metallothionein on the cell surface of Ralstonia eutropha CH34 for immobilization of heavy metals in soil.
(2000) Nature Biotechnology 18:661-5.