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Cell endomembrane system and plant response to stress

Plants are sessile organisms that can not escape from the many biotic and abiotic aggressions they suffer, but have to adapt themselves to the varying environmental conditions, to achieve growth and reproduction. Cell metabolism and endomembrane construction are two interconnected aspects that plants modulate to withstand the stress situations.

We are interested in the mechanisms involved in these processes. In particular, we are investigating the role of 3-hydroxy-3-methylglutaryl Coenzyme A reductase and protein phosphatase 2A in the plant response to stress. Our results indicate that the interaction between these two factors induces the biogenesis of specific domains of the endoplasmic reticulum, which are directly and rapidly delivered to the vacuole in response to stress. This phenomenon involves a dynamic organization of the endoplasmic reticulum, under control of signal transduction pathways that we are deciphering at present.

Selected Publications

Pollier J, Moses T, González-Guzmán M, De Geyter N, Lippens S, Bossche RV, Marhavý P, Kremer A, Morreel K, Guérin CJ, Tava A, Oleszek W, Thevelein JM, Campos N, Goormachtig S, Goossens A.

The protein quality control system manages plant defence compound synthesis

Nature 2013; doi: 10.1038/nature12685


Antolín-Llovera M, Leivar P, Arró M, Ferrer A, Boronat A, Campos N

Modulation of HMG-CoA reductase by protein phosphatase 2A: positive and negative control at a key node of metabolism

Plant Signaling & Behavior 2011; 6:1127-1131


Leivar P, Antolín-Llovera M, Ferrero S, Closa M, Arró M, Ferrer A, Boronat A, Campos N

Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl Coenzyme A reductase by protein phosphatase 2A

Plant Cell 2011; 23:1494-1511