Plants are sessile organisms that can not escape from the many biotic and abiotic aggressions they suffer, but have to adapt themselves to the varying environmental conditions, to achieve growth and reproduction. Cell metabolism and endomembrane construction are two interconnected aspects that plants modulate to withstand the stress situations.
We are interested in the mechanisms involved in these processes. In particular, we are investigating the role of 3-hydroxy-3-methylglutaryl Coenzyme A reductase and protein phosphatase 2A in the plant response to stress. Our results indicate that the interaction between these two factors induces the biogenesis of specific domains of the endoplasmic reticulum, which are directly and rapidly delivered to the vacuole in response to stress. This phenomenon involves a dynamic organization of the endoplasmic reticulum, under control of signal transduction pathways that we are deciphering at present.