Molecular Reprogramming and Evolution

Molecular Reprogramming and Evolution

Group Leaders
Ignacio Rubio-Somoza
Ramón y Cajal Researcher
Group Members
Molecular Reprogramming and Evolution (MoRE) group

Postdoctoral Researchers

PhD Students

General research support

Overview

The main scope of our research is in understanding how plants interrelate with their surrounding environment. We are especially interested on the molecular mechanisms that allow plants to perceive and cope with the presence of pathogen threats. Our main line of research focuses on the cellular events triggered by the intracellular presence of pathogen-derived RNA silencing suppressors and its consequences both for plant development and defence reprogramming. Another line of research in the lab focuses on studying the evolution of hormone-mediated plant-microbe communication. In both lines of research, we are leveraging state-of-the-art techniques based on next generation sequencing, cell and molecular biology.

Selected Publications

Von Born, P., Bernardo-Faura, M., Rubio-Somoza, I.
An artificial miRNA system reveals that relative contribution of translational inhibition to miRNA-mediated regulation depends on environmental and developmental factors in Arabidopsis thaliana
(2018) PLoS ONE, vol. 13 (2), Art. number e0192984

Salvador-Guirao R, Baldrich P, Weigel D, Rubio-Somoza I*, San Segundo B*
The microRNA 773 is involved in the Arabidopsis immune response to fungal pathogens. 
(2018) Molecular Plant Microbe Interactions 31: 249-259

Soto-Suárez, M., Baldrich, P., Weigel, D., Rubio-Somoza, I*., San Segundo, B.*
The Arabidopsis miR396 mediates pathogen-associated molecular pattern-triggered immune responses against fungal pathogens
(2017) Scientific Reports, vol. 7, Art. number 44898

Martinho, C., Confraria, A., Elias, C.A., Crozet, P., Rubio-Somoza, I., Weigel, D., Baena-González, E.
Dissection of miRNA pathways using Arabidopsis mesophyll protoplasts
(2015) Molecular Plant, vol. 8 (2), pp. 261-275

Rubio-Somoza I, Zhang Y-C, Confraria A, Martinho C, von Born P, Baena-Gonzalez E, Wang J-W and Weigel D. 
Temporal control of leaf complexity by miRNA-controlled licensing of protein complexes. 
(2014) Current Biology 24(22): 2714-2719.

Rubio-Somoza I.* and Weigel D.
Coordination of flower maturation by a regulatory circuit of three microRNAs. 
(2013). PLoS Genetics 9(3), e1003374.

Rubio-Somoza I* and Weigel D.
MiRNA networks and plant developmental plasticity. 
(2011) Trends in Plant Science 16(5), 258-264. 

Todesco M*, Rubio-Somoza I*, Paz-Ares J and Weigel D.
A collection of target mimics for comprehensive análisis of microRNA function in Arabidopsis Thaliana. 
(2010) PLoS Genetics 6(7), e1001031. 

Franco-Zorrilla JM, Valli A, Todesco M, Mateos I, Puga MI, Rubio-Somoza I, Leyva A, Weigel D, García JA and Paz-Ares J. 
Target mimicry provides a novel mechanism for regulation of microRNA Activity. 
(2007) Nature Genetics 39, 1033-1037.