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Molecular Reprogramming and Evolution
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Overview
The main scope of our research is in understanding how plants interrelate with their surrounding environment. We are especially interested on the molecular mechanisms that allow plants to perceive and cope with the presence of pathogen threats. Our main line of research focuses on the cellular events triggered by the intracellular presence of pathogen-derived RNA silencing suppressors and its consequences both for plant development and defence reprogramming. Another line of research in the lab focuses on studying the evolution of hormone-mediated plant-microbe communication. In both lines of research, we are leveraging state-of-the-art techniques based on next generation sequencing, cell and molecular biology.
Selected Publications
Alessandro Silvestri, William Conrad Ledford, Valentina Fiorilli , Cristina Votta , Alessia Scerna, Jacopo Tucconi, Antonio Mocchetti, Gianluca Grasso, Raffaella Balestrini, Hailing Jin, Ignacio Rubio-Somoza* and Luisa Lanfranco*
A fungal sRNA silences a host plant transcription factor to promote arbuscular mycorrhizal symbiosis
(2024) New Phytologist (DOI:10.1111/nph.20273)
Ros-Moner E.; Jiménez-Góngora T.; Villar-Martín L.; Vogrinec L.; González-Miguel V.M.; Kutnjak D.; Rubio-Somoza I.
Conservation of molecular responses upon viral infection in the non-vascular plant Marchantia polymorpha
(2024) Nature Communications , vol. 15 (1), Art. number 8326 (DOI:10.1038/s41467-024-52610-0)
Francois Vasseur, Patricia Baldrich, Tamara Jiménez-Góngora, Luis Villar-Martin, Detlef Weigel, and Ignacio Rubio-Somoza
miR472 deficiency enhances Arabidopsis thaliana defense without reducing seed production
(2024) DOI:10.1094/MPMI-02-24-0011-R
Silvestri A.; Bansal C.; Rubio-Somoza I.
After silencing suppression: miRNA targets strike back
(2024) Trends in Plant Science, (Article in press), (DOI:10.1016/j.tplants.2024.05.001)
Ledford W.C.; Silvestri A.; Fiorilli V.; Roth R.; Rubio-Somoza I*; Lanfranco L*
A journey into the world of small RNAs in the arbuscular mycorrhizal symbiosis
(2024) New Phytologist, vol. 242 (4), pp. 1534 -1544 (DOI:10.1111/nph.19394)
Von Born, P., Bernardo-Faura, M., Rubio-Somoza, I.
An artificial miRNA system reveals that relative contribution of translational inhibition to miRNA-mediated regulation depends on environmental and developmental factors in Arabidopsis thaliana
(2018) PLoS ONE, vol. 13 (2), Art. number e0192984
Salvador-Guirao R, Baldrich P, Weigel D, Rubio-Somoza I*, San Segundo B*
The microRNA 773 is involved in the Arabidopsis immune response to fungal pathogens.
(2018) Molecular Plant Microbe Interactions 31: 249-259
Soto-Suárez, M., Baldrich, P., Weigel, D., Rubio-Somoza, I*., San Segundo, B.*
The Arabidopsis miR396 mediates pathogen-associated molecular pattern-triggered immune responses against fungal pathogens
(2017) Scientific Reports, vol. 7, Art. number 44898
Martinho, C., Confraria, A., Elias, C.A., Crozet, P., Rubio-Somoza, I., Weigel, D., Baena-González, E.
Dissection of miRNA pathways using Arabidopsis mesophyll protoplasts
(2015) Molecular Plant, vol. 8 (2), pp. 261-275
Rubio-Somoza I, Zhang Y-C, Confraria A, Martinho C, von Born P, Baena-Gonzalez E, Wang J-W and Weigel D.
Temporal control of leaf complexity by miRNA-controlled licensing of protein complexes.
(2014) Current Biology 24(22): 2714-2719.
Rubio-Somoza I.* and Weigel D.
Coordination of flower maturation by a regulatory circuit of three microRNAs.
(2013). PLoS Genetics 9(3), e1003374.
Rubio-Somoza I* and Weigel D.
MiRNA networks and plant developmental plasticity.
(2011) Trends in Plant Science 16(5), 258-264.
Todesco M*, Rubio-Somoza I*, Paz-Ares J and Weigel D.
A collection of target mimics for comprehensive análisis of microRNA function in Arabidopsis Thaliana.
(2010) PLoS Genetics 6(7), e1001031.
Franco-Zorrilla JM, Valli A, Todesco M, Mateos I, Puga MI, Rubio-Somoza I, Leyva A, Weigel D, García JA and Paz-Ares J.
Target mimicry provides a novel mechanism for regulation of microRNA Activity.
(2007) Nature Genetics 39, 1033-1037.