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Plant viruses

The group intends the control of plant pathogenic viruses through interference with the transmission processes, and through the use of genetic resistance. The mechanisms of vector transmission of viruses by insects mediated by viral-encoded components, such as the aphid transmission factor of potyviruses known as HCPro, are being contemplated. Additional aspects of research involve virus infection and pathogenicity of emergent virus diseases, including whitefly transmitted ipomoviruses, and the suppression of RNA silencing by viral products.

The objectives on genetic resistance are mainly focused on Cucumber Mosaic virus in melon. A gene (cmv1) responsible for total resistance against some CMV strains but unable to stop other set of strains has been identifyed, and other two QTLs (cmv2 and cmv3) that must act together with cmv1 to produce resistance to the other set of CMV strains are under study, indicating that the resistance to CMV in melon is complex and composed of at least two levels. The viral part of the interaction with the gene cmv1, the Movement Protein, is also addressed to understand how this interaction interferes with the movement of the virus in the resistant plant.

Selected Publications

C. Guiu-Aragonés, J.A. Díaz-Pendón and A.M. Martín-Hernández

Four sequence positions of the Movement Protein of Cucumber mosaic virus determine the virulence against cmv1-mediated resistance in melon.

Mol. Plant. Pathology, 16: 675-684. (2015) 


Rodamilans B, Valli A, Mingot A, San Leon D, Baulcombe D, Lopez-Moya JJ, Garcia JA

RNA polymerase slippage as a mechanism for the production of frameshift gene products in plant viruses of the Potyviridae family.

Journal of Virology 89, 6965-6967.(2015) 


J. Argyris, M. Pujol, Marta; A.M. Martín-Hernández, and J. Garcia-Mas

Combined use of genetic and genomics resources to understand virus resistance and fruit quality traits in melon.

Physiologia Plantarum, 155: 4–11 (2015)


Navas Castillo J, López-Moya JJ, Aranda MA

Whitefly-transmitted RNA viruses that affect intensive vegetable production. Annals of Applied Biology.

 (2014) 165 - 2, pp. 155 - 171


Baldrich P., Kakar K., Sire C., Moreno A.B., Berger A., Garcia-Chapa M., Lopez-Moya J.J., Riechmann J.L., San Segundo B. 

Small RNA profiling reveals regulation of Arabidopsis miR168 and heterochromatic siRNA415 in response to fungal elicitors

BMC Genomics, vol. 15 (1), Art. number 1083. (2014) 


C. Guiu-Aragonés, A.J. Monforte, M.Saladié,  R.X. Corrêa, J. Garcia-Mas  and A.M. Martín-Hernández.

The complex resistance to Cucumber Mosaic Cucumovirus (CMV) in the melon accession PI161375 is governed by one gene and at least two QTLs.

Mol Breeding, 34:351-362 (2014).


Bragard C, Caciagli P, Lemaire O, Lopez-Moya JJ, MacFarlane S, Peters D, Susi P, Torrance L.

Status and prospects of plant virus control through interference with vector transmission

Annu Rev Phytopathol. 2013;51:177-201


Giner A, Lakatos L, García-Chapa M, López-Moya JJ, Burgyán J.

Viral protein inhibits RISC activity by argonaute binding through conserved WG/GW motifs

PLoS Pathog. 2010 Jul 15;6(7):e1000996


Fernández-Calvino L, Goytia E, López-Abella D, Giner A, Urizarna M, Vilaplana L, López-Moya JJ.

The helper-component protease transmission factor of Tobacco etch potyvirus binds specifically to an aphid ribosomal protein homologous to the laminin receptor precursor

J Gen Virol. 2010 Nov;91(Pt 11):2862-73


Essafi A, Díaz-Pendón JA, Moriones E, Monforte AJ, Garcia-Mas J, Martín-Hernández AM.

Dissection of the oligogenic resistance to Cucumber mosaic virus in the melon accession PI 161375

Theor Appl Genet. 2009 Jan;118(2):275-84