RNA biology

Group Leaders
Nicolas Bologna
Junior Leader Incoming Fellowship la Caixa
Group Members
RNA Biology group

Postdoctoral Researchers

General research support

Overview

The purpose of our laboratory in the study of RNA-guided gene regulation focused on the function of small and long non-coding RNAs guiding novel nuclear events. We are performing a detailed analysis of nuclear RNA processes by studying the identity, localization, and functions of specific nuclear RNA molecules, nuclear RNA/proteins complexes and nuclear shuttling processes in Arabidopsis thaliana and Caenorhabditis elegans. Through these analyses, we expect to characterize novel nuclear RNA pathways and to uncover their biological relevance.

Selected Publications

Bologna NG, Iselin R, Abriata L, Sarazin A, Pumplin N, Jay F, Grentzinger T, Dal Peraro M, Voinnet O. 
Nucleo-cytosolic shuttling of ARGONAUTE1 prompts a revised model of the plant microRNA pathway. 
(2018)  Molecular Cell, 69(4), 709–719.e5.

Bologna NG, Voinnet O. 
The diversity, biogenesis, and activities of endogenous silencing small RNAs in Arabidopsis. 
(2014)  Annu Rev Plant Biol. 65:473-503.

Bologna NG, Schapire AL, Zhai J, Chorostecki U, Boisbouvier J, Meyers BC, Palatnik JF. 
Multiple RNA recognition patterns during microRNA biogenesis in plants. 
(2013)  Genome Res. 23(10):1675-89.

Schapire AL*, Bologna NG*, Moro B, Zhai J, Meyers BC, Palatnik JF. 
Construction of Specific Parallel Amplification of RNA Ends (SPARE) libraries for the systematic identification of plant microRNA processing intermediates. 
(2013) Methods. 64(3):283-91. 
*These authors contributed equally to this work.

Bologna NG, Schapire AL, Palatnik JF. 
Processing of plant microRNA precursors. 
(2013) Brief Funct Genomics. 12(1):37-45.

Bologna NG, Mateos JL, Bresso EG, and Palatnik JF.
A loop-to-base processing mechanism underlies the biogenesis of plant microRNAs miR319 and miR159.  
(2009) EMBO J. 28(23):3646-56.