• Català
  • English
  • Español

Role of SUMO in plant development

In plants, SUMOylation regulates essential processes and a functional SUMOylation system is required for embryo viability. In general, mutant plants affected in SUMO conjugation homeostasis display growth defects, but a few positive and agronomic interesting phenotypes have also been identified, such as resistance to bacterial pathogens and salt tolerance. In order to gain new insights into SUMO conjugation in plants and to eventually engineering plants with improved agronomic traits, we address the following questions:

1.- Uncovering regulatory mechanisms that modulate SUMO conjugation in planta.

2.- Development of molecular tools for diminishing SUMOylation in order to improve plant agronomical traits by selective SUMO conjugation inhibition.

3.- Study of the molecular basis of SUMO biological function by identifying SUMO conjugates and SUMO interacting partners.

4.- Contribution of SUMOylation to ABA signaling in seeds.

Selected Publications

Castaño-Miquel, L., Seguí, J., Manrique, S., Teixeira, I., Carretero-Paulet, L., Atencio, F., and Lois, L. M.

Diversification of SUMO-Activating Enzyme in Arabidopsis: Implications in SUMO Conjugation

Molecular plant 6, 1646-1660

 

Castaño-Miquel, L., Seguí, J., and Lois, L. M. (2011)

Distinctive properties of Arabidopsis SUMO paralogues support the in vivo predominant role of AtSUMO1/2 isoforms

Biochemical Journal 436, 581-590

 

Lois, L. M. (2010)

Diversity of the SUMOylation machinery in plants

Biochemical Society transactions 38, 60-64

 

Chosed, R., Mukherjee, S., Lois, L. M., and Orth, K. (2006)

Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation

Biochemical Journal 398, 521-529

 

Lois, L. M., and Lima, C. D. (2005)

Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1

EMBO J 24, 439-451