Systems Biology of Plant Responses to Stress

Group Leaders
Group Members


Our group is interested in investigating how plants respond to adverse environments from a systemic perspective. To this end, we conduct high-throughput profiling and systems-wide analysis of transcriptome, proteomes and metabolomes changes in plants exposed to broad ranges of abiotic and biotic stressors in single and combinatorial designs. Our research is mainly based on the model plant Arabidopsis thaliana, but also extend our focus to other plants of agronomical interest, such as tomato, rice, and melon. The main goals of the group are: (i) the reconstruction of networks to provide holistic interpretations and decipher novel components in plant responses to stress; (ii) the identification of evolutionary-driven strategies for plant adaptation to adverse environments, (iii) the combination of Molecular Biology with Bioinformatics to elaborate predictive models that anticipate plant responses to frequent environmental perturbations and (iv) the assistance with experimental designs and data analysis to stablish synergies with other research groups in the field.

Selected Publications

Garcia-Molina, A.; Pastor, V.
Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens.
(2023) Plant Commun. 5-1: 1000645.

Garcia-Molina, A.; Lehmann, M.; Schneider, K.; Klingl, A.; Leister, D.
Inactivation of cytosolic FUMARASE2 enhances growth and photosynthesis under simultaneous copper and iron deprivation in Arabidopsis.
(2021) Plant J. 106-3, pp. 766-784.

Garcia-Molina, A.; Marino, G.; Lehmann, M.; Leister, D.
Systems biology of responses to simultaneous copper and iron deficiency in Arabidopsis.
(2020) Plant J. 103-6, pp. 2119-2138.

Garcia-Molina, A.; Kleine, T.; Schneider, K.; Mühlhaus, T.; Leister, D.
Translational components contribute to acclimation responses to high light, heat and cold in Arabidopsis.
(2020) iScience. 23, pp. 101331.

Garcia-Molina, A.; Leister, D.
Accelerated relaxation of photoprotection impairs biomass accumulation in Arabidopsis.
(2020) Nat Plants.

Garcia-Molina, A.; Altmann, M.; Alkofer, A.; Epple, P.M.; Dangl, J.L.; Falter-Braun, P.
LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2.
(2017)  J Exp Bot. 68-5, pp.1185-1197.

Garcia-Molina, A.; Xing, S.; Huijser, P.
Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response.
(2014) BMC Plant Biol. 14-1, pp.231.

Garcia-Molina, A.; Xing, S.; Huijser, P.
A conserved KIN17 curved DNA-binding domain protein assembles with SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE7 to adapt Arabidopsis growth and development to limiting copper availability.
(2013) Plant Phys. 164-2, pp. 828-840.

Garcia-Molina, A.; Andrés-Colás, N.; Pérea-García, A.; Neumann, U.; Dodani, S.C.; Huijser, P.; Peñarrubia, L.Puig, S.
The Arabidopsis COPT6 transport protein functions in copper distribution under copper-deficient conditions.
(2013) Plant Cell Phys. 54-8, pp. 1378-90.

Pérea-García, A.; Garcia-Molina, A.; Andrés-Colás, N.; Vera-Sirera, F.; Pérez-Amador, M.A.; Puig, S.; Peñarrubia, L.
Arabidopsis copper transport protein COPT2 participates in the cross talk between iron deficiency responses and low-phosphate signaling.
(2013) Plant Phys. 162-1, pp. 180-194.

Garcia-Molina, A.; Andrés-Colás, N.; Perea-García, A.; del Valle-Tascón, S.; Peñarrubia, L.; Puig, S.
The intracellular Arabidopsis COPT5 transport protein is required for photosynthetic electron transport under severe copper deficiency.
(2011) Plant J. 65-6, pp.848-860.