Plants are a primary source of nutrients, chemicals, and materials for humans. Our program aims to generate fundamental knowledge on plant physiology and metabolism and to use this knowledge to improve crops through plant synthetic and metabolic engineering approaches. We are interested in deciphering the control of primary and secondary metabolism for the production of high-quality bioproducts and the enhancement of plant performance and yield. Furthermore, by using a synthetic biology framework, we aim to contribute to the advancement of basic plant research and provide novel biotechnological tools.

In particular, our Program addresses the study of the regulation of isoprenoid and lignin biosynthetic pathways, the organization of the cell endomembrane system, the fixation of carbon through photosynthesis, and the development of microalgae as a bioengineering and synthetic biology platform. These pathways and processes impact yield, fruit and seed quality, nutritional content, digestibility, bioenergetic value, and tolerance to biotic and abiotic stress. Our work aims to develop technologies to reprogram plant cells, including the design of genetic circuits for fine tuning gene expression, the design of novel metabolic pathways, and the use of plant cells as biofactories to express molecules of therapeutic interest.

The experimental approaches emerge from the biochemistry, genetics, molecular, and cell biology fields, and include advanced plant/microalgae system methodologies with transcriptomic, proteomic and metabolomic analyses. A substantial part of the research activities is performed in well-established models (Marchantia or Arabidopsis), crop plants (tomato, rice, and maize), and microalgae (Chlamydomonas and Chlorella).


Castaño-Miquel L., Lois L.M.

Kinetic Analysis of Plant SUMO Conjugation Machinery (2023) Methods in Molecular Biology, vol. 2581 pp. 93 -108 (DOI:10.1007/978-1-0716-2784-6_8)

Lois L.M., Trujillo M.

Preface “Plant Proteostasis” (2023) Methods in Molecular Biology, vol. 2581 pp. v -vii

Hwang H.G., Milito A., Yang J.-S., Jang S., Jung G.Y.

Riboswitch-guided chalcone synthase engineering and metabolic flux optimization for enhanced production of flavonoids (2023) Metabolic Engineering, vol. 75 pp. 143 -152 (DOI:10.1016/j.ymben.2022.12.006)

Chávez A., Castillo N., López-Tubau J.M., Atanasov K.E., Fernández-Crespo E., Camañes G., Altabella T., Ferrer A.

Tomato STEROL GLYCOSYLTRANSFERASE 1 silencing unveils a major role of steryl glycosides in plant and fruit development (2023) Environmental and Experimental Botany, vol. 206 Art. number 105181 (DOI:10.1016/j.envexpbot.2022.105181)

Muleya V., Lois L.M., Chahtane H., Thomas L., Chiapello M., Marondedze C.

(De)Activation (Ir)Reversibly or Degradation: Dynamics of Post-Translational Protein Modifications in Plants (2022) Life, vol. 12 (2), Art. number 324 (DOI:10.3390/life12020324)